Advantage of autologous blood transfusion in surgery for hepatocellular carcinoma

作者：Tomimaru Yoshito; Eguchi Hidetoshi; Marubashi Shigeru; Wada Hiroshi; Kobayashi Shogo; Tanemura Masahiro; Umeshita Koji; Doki Yuichiro; Mori Masaki; Nagano Hiroaki^*

来源：World Journal of Gastroenterology, 2011, 17(32): 3709-3715.

DOI：10.3748/wjg.v17.i32.3709

• Hepatocellular carcinoma
• Surgery
• Autologous blood transfusion
• Homologous blood transfusion

AIM: To evaluate the significance of autologous blood transfusion (AT) in reducing homologous blood transfusion (HT) in surgery for hepatocellular carcinoma (HCC).
METHODS: The proportion of patients who received HT was compared between two groups determined by the time of AT introduction; period A (1991-1994, n = 93) and period B (1995-2000, n = 201). Multivariate logistic regression analysis was performed in order to identify independent significant predictors of the need for HT. We also investigated the impact of AT and HT on long-term postoperative outcome after curative surgery for HCC.
RESULTS: The proportion of patients with HT was significantly lower in period B than period A (18.9% vs 60.2%, P < 0.0001). Multivariate logistic regression analysis identified AT administration as a significant independent predictor of the need for HT (P < 0.0001). Disease-free survival in patients with AT was comparable to that without any transfusion. Multivariate analysis identified HT administration as an independent significant factor for poorer disease-free survival (P = 0.0380).
CONCLUSION: AT administration significantly decreased the need for HT. Considering the postoperative survival disadvantage of HT, AT administration could improve the long-term outcome of HCC patients.

• 出版日期2011-8-28