A T-1, T-2 magnetic resonance imaging (MRI)-fluorescent imaging (FI) by using ultrasmall mixed gadolinium-europium oxide nanoparticles

作者：Xu Wenlong; Park Ja Young; Kattel Krishna; Bony Badrul Alam; Heo Woo Chou; Jin Seonguk; Park Jang Woo; Chang Yongmin^*; Do Ji Yeon; Chae Kwon Seok; Kim Tae Jeong; Park Ji Ae; Kwak Young Woo; Lee Gang Ho

来源：New Journal of Chemistry, 2012, 36(11): 2361-2367.

DOI：10.1039/c2nj40149e

Multiple molecular imaging is a challenging subject. Water-soluble and biocompatible lactobionic acid coated ultrasmall mixed gadolinium-europium oxide nanoparticles with an average particle diameter of 1.75 nm and an average hydrodynamic diameter of 4.16 nm were synthesized and applied for T-1, T-2 MRI-FI in vitro and in vivo. They had r(1) and r(2) values of 11.9 and 38.7 s(-1) mM(-1), respectively, and showed clear dose-dependent contrast changes in both R-1 and R-2 map images. In addition, they showed both positive and negative contrast enhancements in 3 testa T-1 and T-2 MR images in a mouse, respectively, and fluorescent confocal images in both DU145 cells and C. elegans (a small nematode). This study demonstrates the T-1, T-2 MRI-FI multi-functionality of lactobionic acid coated mixed gadolinium-europium oxide nanoparticles.

• 出版日期2012-11
• 单位南宁师范大学