Direct benzylation of 1,3-dicarbonyl compounds catalyzed by Cs2.5H0.5PW12O40 in solvent-free conditions

作者：Rafiee Ezzat^*; Khodayari Maryam; Joshaghani Mohammad

来源：Canadian Journal of Chemistry, 2011, 89(12): 1533-1538.

DOI：10.1139/V11-134

• heteropoly salt
• benzylation
• 1,3-dicarbonyl compounds
• nucleophilic substitution
• solvent-free conditions

Various 1,3-dicarbonyl compounds reacted readily with benzylic alcohols in the presence of Cs2.5H0.5PW12O40 salt to produce 2-benzylic-1,3-dicarbonyl compounds in high yields. It was found that this catalyst could be completely recovered and reused without loss of its catalytic activities and is thus environmentally conscious especially in solvent-free conditions. The use of this method provides improved modification of the direct benzylation of 1,3-carbonyl compounds in terms of low reaction times, solvent-free conditions, usage of a small amount of the catalyst, and a clean reaction profile. Furthermore, the use of this catalyst is feasible because of its easy preparation, its easy handling, its stability, its easy recovery, its reusability, being environmentally green, its excellent activity, and its selectivity.

• 出版日期2011-12