Angiotensin-converting enzyme insertion/deletion polymorphism and gastric cancer: A systematic review and meta-analysis

作者：Wei, Ming-Tian; Chen, Nan; He, Ya-Zhou; Wang, Jia-Rong; Yang, Yang; Guo, Xiao-Jiang; Wang, Zi-Qiang^*

来源：Clinics and Research in Hepatology and Gastroenterology, 2015, 39(1): 136-144.

DOI：10.1016/j.clinre.2014.06.015

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Background and objective: Several studies were launched to investigate the potential function of ACEI/D polymorphism in gastric cancer development and prognosis, but no conclusive results have been obtained. We conducted a systematic review and meta-analysis to evaluate the association between ACE I/D polymorphism and gastric cancer. @@@ Methods: A systemic search was performed in PubMed, Embase, China National Knowledge Infrastructure (CNKI), Wanfang and Weipu databases (until October 15,2013) to identify all published records on association between the ACE I/D polymorphism and gastric cancer. We adopted the odds ratio (OR) and 95% confidence interval (95%CI) as measure of effect. Meta analysis was conducted using fixed/random-effects model in STATA 12.0. @@@ Results: Eventually a total of seven studies with 1392 cases and 2951 controls were included in our meta-analysis. No association was detected between ACE I/D polymorphism and gastric cancer susceptibility (DI + DD vs II: OR= 1.06, 95%CI=0.92-1.21, P = 0.443). However, we found that the DD genotype was significantly associated with increased lymph node metastasis (DD vs DI + II: OR- 3.48, CI = 1.77-6.85, P < 0.001), and more advanced clinical stage (DD vs DI + II: OR =2.43, CI =1.34-4.39, P = 0.003) of gastric cancer. @@@ Conclusion: Our results indicated that ACE I/D polymorphism could not be directly associated with gastric cancer susceptibility, but might play important role in gastric cancer prognosis. Future studies with larger sample size are warranted for further evaluation.

• 出版日期2015-2
• 单位四川大学