Hepatocyte transporter expression in FNH and FNH-like nodule: correlation with signal intensity on gadoxetic acid enhanced magnetic resonance images

作者：Yoneda Norihide^*; Matsui Osamu; Kitao Azusa; Kita Ryuuichi; Kozaka Kazuto; Koda Wataru; Kobayashi Satoshi; Gabata Toshifumi; Ikeda Hiroko; Sato Yasunori; Nakanuma Yasuni

来源：Japanese Journal of Radiology, 2012, 30(6): 499-508.

DOI：10.1007/s11604-012-0085-4

• OATP8
• EOB-MRI
• HB phase
• FNH
• FNH-like nodule

Our aim was to evaluate the hepatocyte transporters in focal nodular hyperplasia (FNH) and FNH-like lesions and to correlate the grade of its expression with signal intensity on the hepatobiliary phase (HB phase) of gadoxetic-acid-enhanced magnetic resonance imaging (EOB-MRI). %26lt;br%26gt;Thirteen histopathological confirmed cases including eight with EOB-MRI were studied. Immunohistochemical staining for transporter was performed and its grade semiquantitatively analyzed. %26lt;br%26gt;Histopathologically, ten cases showed almost equal organic anion transporter polypeptide (OATP) 8 expression relative to the surrounding liver; the remaining three showed stronger OATP8 expression. In eight cases with EOB-MRI, two demonstrated more hyperintensity on the HB phase, and their OATP8 expression was stronger compared with the surrounding liver. The remaining six cases showed isointensity on the HB phase and revealed almost equal OATP8 expression. The expression of export transporter multi-drug-resistant proteins (MRP) 1 and 2 were almost equal relative to the surrounding liver in most cases (11/12, 92 %; 11/12, 92 %, respectively), whereas MRP3 focally overexpressed in 75 % (9/12) of cases. %26lt;br%26gt;FNH and FNH-like nodules revealed equal or stronger OATP8 expression than background liver. OATP8 expression showed significant correlation with signal intensity on the HB phase.

• 出版日期2012-7