Activation of ER alpha is necessary for estradiol's anorexigenic effect in female rats

作者：Santollo Jessica; Katzenellenbogen Benita S; Katzenellenbogen John A; Eckel Lisa A^*

来源：Hormones and Behavior, 2010, 58(5): 872-877.

DOI：10.1016/j.yhbeh.2010.08.012

• Estradiol
• Food intake
• Estrous cycle
• Estrogen receptor
• MPrP
• PHTPP

While there is considerable evidence that the ovarian hormone estradiol reduces food intake in female rats, it is unclear which estrogen receptor (ER) subtype, ER alpha or ER beta, mediates this effect. While several studies have demonstrated that activation of ER alpha, but not ER beta, is sufficient to reduce food intake in ovariectomized (OVX) rats, there are limited data regarding which receptor subtype is necessary. Here we used the selective ER alpha and ER beta antagonists, MPrP and PHTPP, respectively, to investigate this question. We found that antagonism of ER alpha, but not ER beta, prevented the decrease in food intake following acute administration of estradiol in OVX rats. In addition, antagonism of ER alpha prevented the estrous-related, phasic reduction in food intake that occurs in response to the rise in circulating levels of estradiol in cycling rats. We conclude that activation of ER alpha is necessary for the anorexigenic effects of exogenous and endogenous estradiol in female rats.

• 出版日期2010-11