Unconventional antigen-presenting cells in the induction of peripheral CD8( ) T cell tolerance

作者：Reynoso Erika D; Turley Shannon J^*

来源：Journal of Leukocyte Biology, 2009, 86(4): 795-801.

DOI：10.1189/jlb.0509362

• lymph nodes
• stroma
• parenchymal cell
• nonhematopoietic cell

Bone marrow-derived APCs are considered the predominant cell type involved in the induction and maintenance of T cell tolerance in vivo. In the periphery, cross-presentation of self-antigens by DCs, in particular, CD8 alpha( ) DCs, has been the most discussed mechanism underlying the induction of CD8( ) T cell tolerance against self. However, nonhematopoietic APCs in the liver, skin, parenchymal tissues, and lymph nodes can also present self-and exogenous antigens to CD8( ) T cells under steady-state conditions. Although far surpassed by their DC counterparts in their ability to stimulate T cell responses, these unconventional APCs have been shown to play a role in the induction, maintenance, and regulation of peripheral CD8( ) T cell tolerance by a multitude of mechanisms. In this review, we will discuss the different nonhematopoietic cells that have been shown to present tissue-specific or exogenous antigens to naive CD8( ) T cells, thereby contributing to the regulation of T cell responses in the periphery. J. Leukoc. Biol. 86: 795-801; 2009.

• 出版日期2009-10