Antifouling sesquiterpene from the Indian soft coral, Sinularia kavarattiensis Alderslade and Prita

作者：Mol V P Limna; Raveendran T V; Parameswaran P S; Kunnath R J; Sathyan N

来源：Indian Journal of Marine Sciences, 2010, 39(2): 270-273.

• Soft coral
• Sinularia kavarattiensis
• Sesquiterpene
• Furoic acid
• Balanus amphitrite

A sesquiterpene, (1'E,5'E)-2-(2',6'-dimethylocta-1',5',7'-trienyl)-4-furoic acid [1], was isolated for the first time from the soft coral Sinularia kavarattiensis Alderslade & Prita collected from Gulf of Mannar (Tamil Nadu, India). This compound exhibited considerable larval settlement inhibition properties against the cosmopolitan biofouler, Balanus amphitrite. The observed mean EC(50) value of 11.21 mu g/ml is well within the biological potency cut off set for natural product antifoulants (NPA's). The low EC(50) value and favourable therapeutic ratio (5.16) coupled with its known synthetic routes enhances the potential of 1 as a promising NPA.

• 出版日期2010-6