Antibacterial dihydrobenzopyran and xanthone derivatives from Garcinia cowa stem barks

作者：Siridechakorn Ittipon; Phakhodee Wong; Ritthiwigrom Thunwadee; Promgool Trinop; Deachathai Suwanna; Cheenpracha Sarot; Prawat Uma; Laphookhieo Surat^*

来源：Fitoterapia, 2012, 83(8): 1430-1434.

DOI：10.1016/j.fitote.2012.08.006

• Garcinia cowa
• Clusiaceae
• Dimeric chroman
• Rearranged triprenylxanthone
• Antibacterial activity

Two new compounds, garciniacowol (1) and garciniacowone (2) along with 15 known compounds were isolated from the stem barks of Garcinia cowa. Their structures were determined by intensive spectroscopic methods. The structure of 1 was a symmetrical dimeric dihydrobenzopyran derivative, whereas the framework of 2 was a triprenyl caged-xanthone precursor. The antibacterial activities against Escherichia coli TISTR 780, Salmonella typhimurium TISTR 292, Staphylococcus aureus TISTR 1466, and methicillin-resistant S. aureus (MRSA) SK1 of the isolated compounds were also evaluated. Compounds 2 and 9 exhibited good antibacterial activity against MRSA SK1 with the same minimum inhibitory concentration (MIC) value of 2 mu g/mL Moreover, compound 2 also showed good antibacterial activity against S.

• 出版日期2012-12