Tomography of functional organization in protein-protein interaction network

作者：Huang Jiun Yan^*

来源：Physica A: Statistical Mechanics and Its Applications , 2009, 388(10): 2072-2080.

DOI：10.1016/j.physa.2009.01.023

• Protein-protein interaction (PPI) network
• Saccharomyces cerevisiae
• Correlation
• Module

in recent years, after high throughput PPI data was available, studies have focused on unraveling how proteins organize their functionality from architecture of the PPI network. We examine the functional organization of a PPI network by dividing the network into layered structure around a protein according to shortest path length. We proposed an index, functional correlation, to assess the functional closeness of a specific protein with its l layer neighbors, i.e. proteins having l shortest path length from the center protein. Our results showed that functional correlation decays exponentially with the number of layers within a characteristic l

• 出版日期2009-5-15