Sexual behaviours and the risk of head and neck cancers: a pooled analysis in the International Head and Neck Cancer Epidemiology (INHANCE) consortium

作者：Heck Julia E; Berthiller Julien; Vaccarella Salvatore; Winn Deborah M; Smith Elaine M; Shan'gina Oxana; Schwartz Stephen M; Purdue Mark P; Pilarska Agnieszka; Eluf Neto Jose; Menezes Ana; McClean Michael D; Matos Elena; Koifman Sergio; Kelsey Karl T; Herrero Rolando; Hayes Richard B; Franceschi Silvia; Wuensch Filho Victor; Fernandez Leticia; Daudt Alexander W; Curado Maria Paula; Chen Chu; Castellsague Xavier; Ferro Gilles; Brennan Paul; Boffetta Paolo

来源：International Journal of Epidemiology, 2010, 39(1): 166-181.

DOI：10.1093/ije/dyp350

• Sexual practices
• head and neck cancer
• oropharyngeal neoplasms
• homosexual
• gay men
• risk factors
• pooled analyses

Background Sexual contact may be the means by which head and neck cancer patients are exposed to human papillomavirus (HPV).
Methods We undertook a pooled analysis of four population-based and four hospital-based case-control studies from the International Head and Neck Cancer Epidemiology (INHANCE) consortium, with participants from Argentina, Australia, Brazil, Canada, Cuba, India, Italy, Spain, Poland, Puerto Rico, Russia and the USA. The study included 5642 head and neck cancer cases and 6069 controls. We calculated odds ratios (ORs) of associations between cancer and specific sexual behaviours, including practice of oral sex, number of lifetime sexual partners and oral sex partners, age at sexual debut, a history of same-sex contact and a history of oral-anal contact. Findings were stratified by sex and disease subsite.
Results Cancer of the oropharynx was associated with having a history of six or more lifetime sexual partners [OR = 1.25, 95% confidence interval (CI) 1.01, 1.54] and four or more lifetime oral sex partners (OR = 2.25, 95% CI 1.42, 3.58). Cancer of the tonsil was associated with four or more lifetime oral sex partners (OR = 3.36, 95 % CI 1.32, 8.53), and, among men, with ever having oral sex (OR = 1.59, 95% CI 1.09, 2.33) and with an earlier age at sexual debut (OR = 2.36, 95% CI 1.37, 5.05). Cancer of the base of the tongue was associated with ever having oral sex among women (OR = 4.32, 95% CI 1.06, 17.6), having two sexual partners in comparison with only one (OR = 2.02, 95% CI 1.19, 3.46) and, among men, with a history of same-sex sexual contact (OR = 8.89, 95% CI 2.14, 36.8).
Conclusions Sexual behaviours are associated with cancer risk at the head and neck cancer subsites that have previously been associated with HPV infection.

• 出版日期2010-2