Developing Estimates of Frequency and Intensity of Exposure to Three Types of Metalworking Fluids in a Population-Based Case-Control Study of Bladder Cancer

作者：Friesen Melissa C^*; Park Dong Uk; Colt Joanne S; Baris Dalsu; Schwenn Molly; Karagas Margaret R; Armenti Karla R; Johnson Alison; Silverman Debra T; Stewart Patricia A

来源：American Journal of Industrial Medicine, 2014, 57(8): 915-927.

DOI：10.1002/ajim.22328

• metalworking fluids
• bladder cancer
• case-control study
• retrospective exposure assessment
• exposure prediction model

Background A systematic, transparent, and data-driven approach was developed to estimate frequency and intensity of exposure to straight, soluble, and synthetic/semi-synthetic metalworking fluids (MWFs) within a case-control study of bladder cancer in New England.
Methods We assessed frequency using individual-level information from job-specific questionnaires wherever possible, then derived and applied job group-level patterns to likely exposed jobs with less information. Intensity estimates were calculated using a statistical model developed from measurements and determinants extracted from the published literature.
Results For jobs with probabilities of exposure >= 0.5, median frequencies were 8-10 hr/week, depending on MWF type. Median intensities for these jobs were 2.5, 2.1, and 1.0 mg/m(3) for soluble, straight, and synthetic/semi-synthetic MWFs, respectively.
Conclusions Compared to case-by-case assessment, these data-driven decision rules are transparent and reproducible and may result in less biased estimates. These rules can also aid future exposure assessments of MWFs in population-based studies.

• 出版日期2014-8
• 单位NIH