Mechanisms underlying different responses of plasma triglyceride to high-fat diets in hamsters and mice: Roles of hepatic MTP and triglyceride secretion

作者：Gao, Song; He, Liang; Ding, Yilei; Liu, George^*

来源：Biochemical and Biophysical Research Communications, 2010, 398(4): 619-626.

DOI：10.1016/j.bbrc.2010.05.114

• High-fat diets
• Hamster
• Hypertriglyceridemia
• Hepatic triglyceride secretion
• Microsomal triglyceride transfer protein (MTP)
• Free fatty acid

Hypertriglyceridemia, closely associated with insulin resistance, is induced on high-fat diets (HFD) in humans but not in mouse models. Mechanisms underlying this species difference are still unclear. Hamsters resemble humans in lipoprotein metabolism. Here by comparing the responses to HFD in hamsters and mice, we found that hepatic TG secretion, MTP expression and plasma free fatty acid (FFA) level were increased in hamsters on HID feeding but decreased in mice. Although hepatic steatosis and de novo lipogenesis were induced by HFD feeding in both models, cholesterol biosynthesis was inhibited in mice but not in hamsters. Moreover, in insulin deficient state, HFD increased plasma TG level, hepatic TG secretion. MTP expression and plasma FFA level in both models. In summary, distinct changes of MTP expression, in correlation with hepatic TG secretion, underlie the opposite responses of plasma TG levels to high-fat diets in hamsters and mice. Furthermore, hepatic TG secretion and MTP expression seems to be associated with plasma FFA level and cholesterol biosynthesis but not hepatic steatosis or de novo lipogenesis.

• 出版日期2010-8-6
• 单位北京大学; 首都医科大学; 吉林大学