Muscleblind-like 2: circadian expression in the mammalian pineal gland is controlled by an adrenergic-cAMP mechanism

作者：Kim Jong So; Coon Steven L; Weller Joan L; Blackshaw Seth; Rath Martin F; Moller Morten; Klein David C^*

来源：Journal of Neurochemistry, 2009, 110(2): 756-764.

DOI：10.1111/j.1471-4159.2009.06184.x

• cAMP
• Mbnl2
• muscleblind
• pineal gland
• retina
• RNA splicing

Muscleblind-like 2 (Mbnl2) is a zinc finger protein first identified in Drosophila. It appears to be essential for photoreceptor development and to be involved in RNA splicing. Here we report that Mbnl2 is strongly expressed in the rat pineal gland. The abundance of pineal Mbnl2 transcripts follows a marked circadian rhythm with peak levels approximately sevenfold higher at night than day levels. Mbnl2 protein exhibits a similar rhythm. In vitro studies indicate that the abundance of Mbnl2 transcripts and protein are controlled by an adrenergic/cAMP mechanism.

• 出版日期2009-7