Antimicrobial potentials of endophytic fungi residing in Quercus variabilis and brefeldin A obtained from Cladosporium sp.

作者：Wang, F. W.^*; Jiao, R. H.; Cheng, A. B.; Tan, S. H.; Song, Y. C.

来源：WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY, 2007, 23(1): 79-83.

DOI：10.1007/s11274-006-9195-4

• endophytic fungi
• antimicrobial potentials
• Quercus variabilis
• Cladosporium sp
• brefeldin A

Among 67 endophytic fungi isolated from Quercus variabilis, 53.7% of endophytic fungal fermentation broths displayed growth inhibition on at least one test microorganism, such as pathogenic fungi (Trichophyton rubrum, Candida albicans, Aspergillus niger, Epidermophyton floccosum, Microsporum canis) and bacteria (Escherichia coli, Bacillus subtilis, Pseudomonas fluorescens). Moreover, 19.4% of strains showed a broader antimicrobial spectrum, such as Aspergillus sp., Penicillium sp., Alternaria sp., 20.9% of strains showed strong inhibition (+++) to pathogenic bacteria, while only 7.5% displayed that to test fungi. The most active antifungal strain I(R)9-2, Cladosporium sp. was selected and fermented. From the broth, a secondary metabolite, brefeldin A was obtained. This is the first report on the antimicrobial potentials of endophytic fungi residing in Q. variabilis and isolation of brefeldin A produced by Cladosporium sp.

• 出版日期2007-1
• 单位医药生物技术国家重点实验室; 南京大学