Amniotic fluid CA-125 as a marker of intra-amniotic inflammation associated with preterm delivery: a preliminary single center study

作者：Seong Won Joon^*

来源：Archives of Gynecology and Obstetrics, 2016, 293(1): 55-59.

DOI：10.1007/s00404-015-3775-1

• CA-125
• Intra-amniotic inflammation
• Preterm labor
• Preterm premature rupture of membrane

The purpose of this study was to investigate whether amniotic fluid (AF) CA-125 in patients with preterm labor or preterm premature rupture of membranes can help predict intra-amniotic inflammation (IAI), microbial invasion of the amniotic cavity (MIAC) and imminent delivery.
We recruited 36 women who admitted with impending preterm delivery and suspicious AF infection. AF matrix metalloproteinase-8 (MMP-8), white blood cell (WBC) count, glucose levels, and CA-125 levels were measured, and the MMP-8 bedside rapid test was also performed. AF culture and PCR were subsequently performed to confirm MIAC. We compared AF CA-125 levels according to the presence of IAI or MIAC and assessed its predictive value for delivery within 7 days of admission.
AF CA-125 levels were significantly higher in the IAI group than in the non-IAI group (mean +/- A standard deviation: 5608 +/- A 864 vs 904 +/- A 84 IU/ml; p = 0.001). AF CA-125 levels showed a negative correlation with gestational age and a positive correlation with AF WBC counts and MMP-8 levels. AF CA-125 levels were higher in the MIAC group, though this difference was not statistically significant (p = 0.064). Delivery within 7 days of admission was significantly more common in patients with higher AF CA-125 levels (cut-off: 1650 IU/ml, sensitivity: 71.4 %, specificity: 86.4 %, p = 0.005).
AF CA-125 levels are increased in patients with AF inflammation and can be a predictor of imminent preterm delivery.

• 出版日期2016-1