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摘要
For the exchangeable binary data with random cluster sizes, we use a pairwise likelihood procedure to give a set of approximately optimal unbiased estimating equations for estimating the mean and variance parameters. Theoretical results are obtained establishing the large sample properties of the solutions to the estimating equations. An application to a developmental toxicity study is given. Simulation results show that the pairwise likelihood procedure is valid and performs better than the GEE procedure for the exchangeable binary data.
