Aggravated nausea and vomiting induced by fat emulsion for hyperemesis gravidarum: A case report

作者：Zhao, B.; Li, M.; Ren, C.; Liu, X. Y.; Mei, D.^*

来源：Journal of Clinical Pharmacy and Therapeutics, 2017, 42(5): 618-620.

DOI：10.1111/jcpt.12545

• fat emulsion
• hyperemesis gravidarum
• nausea
• vomiting

What is known and objectiveTotal parental nutrition (TPN) for hyperemesis gravidarum (HG) is generally effective and well-tolerated. We report a case of aggravated nausea and vomiting caused by fat emulsion.
Case descriptionA 40-year-old pregnant woman through IVF was admitted to the hospital at 11-week gestation and diagnosed with HG. During TPN treatment, the patient suffered from aggravated nausea and vomiting. We identified fat emulsion as the most likely culprit using challenge, dechallenge and rechallenge.
What is new and conclusionThis is the first report of fat emulsion aggravating nausea and vomiting in such situation.

• 出版日期2017-10
• 单位中国医学科学院北京协和医院; 华中科技大学