Anal Mucosal Melanoma with KIT-Activating Mutation and Response to Imatinib Therapy - Case Report and Review of the Literature

作者：Satzger Imke^*; Kuettler Uta; Voelker Bernward; Schenck Florian; Kapp Alexander; Gutzmer Ralf

来源：Dermatology, 2010, 220(1): 77-81.

DOI：10.1159/000265558

• Mucosal melanoma, metastatic
• Imatinib
• c-KIT protein expression

Previously an increased frequency of KIT aberrations in mucosal melanomas was reported, whereas c-KIT in most types of cutaneous melanomas does not appear to be of pathogenetic importance. Imatinib has become the standard of care in other cancers with KIT mutations such as gastrointestinal stromal tumors. Recently 12 cases of metastatic melanoma and KIT-activating mutations have been published to be successfully treated with c-KIT blockers such as imatinib, sunitinib, dasatinib or sorafenib. We report here on one of our patients with KIT-activating mutation in metastatic anal mucosal melanoma, who showed a response to imatinib therapy and summarize the available literature regarding this new therapeutic option.

• 出版日期2010