H2SO4-Silica Promoted Direct Formation of beta-Glycosides of N-Acetyl Glycosylamines under Microwave Conditions

作者：Mandal Santanu; Sharma Nayan; Mukhopadhyay Balaram^*

来源：Synlett, 2009, 2009(19): 3111-3114.

DOI：10.1055/s-0029-1218304

• carbohydrates
• glycosylations
• supported catalysis
• microwave
• stereoselective synthesis

N-Acetyl glycosamines are important building blocks for the synthesis of biologically active oligosaccharides. This communication describes a simple direct protocol for the synthesis of beta-glycosides of N-acetyl glycosylamines from easily accessible per-O-acetyl derivatives of of N-acetyl glycosylamines Using H2SO4-silica as promoter under microwave conditions. The protocol is suitable for alcohol or Sugar acceptors.

• 出版日期2009-12-1