Accessing a small library of pluripotent 1,4,5-trisubstituted 1H-1,2,3-triazoles via diversity-oriented synthesis

作者：Ajay Arya; Gupt Munna Prasad; Devender N; Tripathi Rama P^*

来源：Molecular Diversity, 2012, 16(2): 335-350.

DOI：10.1007/s11030-012-9369-y

• beta-Amino alocohols
• Benzoxazoles
• Dipolar cycloaddition
• Diversity-oriented synthesis
• 1,4,5-Trisubstituted-1H-1,2,3-triazoles

Diversity-oriented synthesis of structurally different, novel and small drug like molecules based on 1,4,5-trisubstituted 1,2,3-triazoles is developed in a streamlined sequence of different sets of reactions. The method involves the use of simple, readily available and highly economical substrates and reagents. The molecules developed herein have potential to be exploited either as chemotherapeutic agents or as scaffolds for other biologically active compounds.

• 出版日期2012-5