Maternal intake of vitamin D during pregnancy and risk of advanced beta cell autoimmunity and type 1 diabetes in offspring

作者：Marjamaki L; Niinisto S^*; Kenward M G; Uusitalo L; Uusitalo U; Ovaskainen M L; Kronberg Kippila C; Simell O; Veijola R; Ilonen J; Knip M; Virtanen S M

来源：Diabetologia, 2010, 53(8): 1599-1607.

DOI：10.1007/s00125-010-1734-8

• Beta cell autoimmunity
• Children
• Cohort
• Population-based studies
• Pregnancy
• Type 1 diabetes
• Vitamin D

We evaluated the intake of vitamin D by pregnant Finnish women and examined associations between maternal intake of vitamin D and the development of advanced beta cell autoimmunity and type 1 diabetes in their offspring.
The research was carried out within the Diabetes Prediction and Prevention study (DIPP), which is a population-based birth cohort of infants at genetic risk of type 1 diabetes. Mothers of 3,723 infants born between 1997 and 2002 completed a validated 181-item food frequency questionnaire, which included questions on dietary supplements. The offspring were observed at 3 to 12 month intervals for the appearance of autoantibodies associated with type 1 diabetes and for the development of clinical type 1 diabetes.
Maternal mean daily intake of vitamin D was 5.1 A mu g from food and 1.3 A mu g from supplements. The maternal intake of vitamin D, either from food or from supplements, was not associated with the risk of advanced beta cell autoimmunity/type 1 diabetes in offspring (HR [95% CI] for intake of vitamin D from food 1.25 [0.80-1.95], for vitamin D intake from supplements 1.05 [0.95-1.16]), or with the risk of type 1 diabetes alone (HR [95% CI] for intake of vitamin D from food 0.84 [0.41-1.72], for vitamin D intake from supplements 1.09 [0.99-1.20]).
Maternal intake of vitamin D either from food or supplements during pregnancy is not associated with advanced beta cell autoimmunity/type 1 diabetes or with type 1 diabetes alone in Finnish offspring carrying increased genetic susceptibility to type 1 diabetes.

• 出版日期2010-8