Emergence of new variants of ST131 clonal group among extraintestinal pathogenic Escherichia coli producing extended-spectrum beta-lactamases

作者：Dahbi Ghizlane; Mora Azucena; Lopez Cecilia; Pilar Alonso Maria; Mamani Rosalia; Marzoa Juan; Coira Amparo; Garcia Garrote Fernando; Maria Pita Julia; Velasco David; Herrera Alexandra; Viso Susana; Blanco Jesus E; Blanco Miguel; Blanco Jorge

来源：International Journal of Antimicrobial Agents, 2013, 42(4): 347-351.

DOI：10.1016/j.ijantimicag.2013.06.017

• Escherichia coli
• ESBL
• CTX-M-15
• ST131

Having shown that Lucus Augusti Hospital in Lugo, Spain, has been affected by Escherichia coli clone O25:H4-ST131 producing CTX-M-15, the present study was carried out to evaluate the prevalence of this clone among the extended-spectrum beta-lactamase (ESBL)-producing E. coli isolates and to identify novel variants of this clone. Of the 77 ESBL-producing E. coli isolated between January and April 2012, 47 (61%) were identified as belonging to the ST131 clonal group, comprising 38 O25b:H4-B2-ST131 (34 CTX-M-15, 2 CTX-M-14, 1 CTX-M-1 and 1 CTX-M-27), 7 O-non-typeable:H4-B2-ST131 (all CTX-M-15) and 2 O16:H5-B2-ST131 (both CTX-M-14). The 47 isolates of ST131 exhibited a significantly higher virulence score (mean of 9.1 virulence genes) compared with the 30 non-ST131 isolates (mean of 4.3 virulence genes). A new virulence profile (fimH, papG II, sat, cnf1, hlyA, iucD, kpsM II-K5, traT, malX, usp) was detected among O25b: H4-B2-ST131 isolates belonging to the new Pasteur sequence type PST621. To our knowledge, this is the first study to report the O-non-typeable: H4-B2-ST131 and O16: H5-B2-ST131 variants in Europe.

• 出版日期2013-10