A Survey of Urolithiasis in Young Children Fed Infant Formula Contaminated with Melamine in Two Townships of Gansu, China

作者：Shi Guo Qing; Wang Zi Jun; Feng Zi Jian; Gao Yong Jun; Liu Jian Di; Shen Tao; Li Ming; Yang Jin; Xu Hai Bing; Jiang Xiao Hong; Wang Zhao Nan; Cai Mei; Wang Yu Min; Zhu Ye Fan; Liu Hui Hui; Wang Rui; Xiong Wei Yi; Wang Zhu Tian; Yang Wei Zhong; Hou Pei Sen; Zeng Guang; Wang Yu

来源：Biomedical and Environmental Sciences, 2012, 25(2): 149-155.

DOI：10.3967/0895-3988.2012.02.004

• Urolithiasis
• Melamine
• Infant formula
• Contamination

Objective To determine the prevalence of urolithiasis in young children fed infant formula (IF) contaminated with melamine, and the association between IF consumption and urolithiasis. @@@ Design A total of 2 733 children <= 3 years of age on September 1, 2008 in two townships of Gansu Province, China were studied. Cases of urolithiasis were diagnosed by ultrasonography. Milk product consumption was determined by their caregivers. Remaining IF samples were tested for melamine and cyanuric acid. @@@ Results Of 2 733 eligible children in the two townships, 2 186 (80%) were enrolled in our study. Overall, 16.6% (362) of 2 186 children had urolithiasis. The prevalence was 24.6% in children exclusively fed Sanlu brand IF, 9.7% in those fed other IF, and 8.5% in those fed exclusively on other milk products. For children exclusively breast-fed, no urolithiasis was found (P<0.05). The prevalence of urolithiasis was 11.4% in children fed 400 g of Sanlu IF, rising to 37.5% in children fed over 25 600 g. Of 48 Sanlu IF samples, 91.7% contained melamine (median=1 800 ppm; range=45-4 700) and 66.7% contained cyanuric acid (median=1.2 ppm; range=0.4-6.3). Melamine was also detected in 22.2% of 36 other brand IF (median=27.5 ppm, range=4-50). @@@ Conclusions Urolithiasis was associated with melamine-contaminated IF. Although one product caused most morbidity, other milk products may have also contributed to the outbreak.

• 出版日期2012-4
• 单位中国疾病预防控制中心; 甘肃省疾病预防控制中心