Neural mechanisms and potential treatment of epilepsy and its complications

作者：Liu, Tao-Tao; He, Zhi-Gang; Tian, Xue-Bi; Xiang, Hong-Bing^*

来源：American Journal of Translational Research, 2014, 6(6): 625-630.

• Intractable epilepsy
• neural inflammatory responses
• melanocortin circuits
• pedunculopontine tegmental nucleus

The factors underlying epilepsy are multifaceted, but recent research suggests that the brain's neural circuits, which play a key role in controlling the balance between epileptic and antiepileptic factors, may lie at the heart of epilepsy. This article provides a comprehensive review of the neural mechanisms and potential treatment of intractable epilepsy from neural inflammatory responses, melanocortin circuits in brain and pedunculopontine tegmental nucleus. Further studies should be undertaken to elucidate the nature of neural circuits so that we may more effectively apply these new preventive and symptomatic therapies to the patient suffering from medically refractory seizures and its complications.

• 出版日期2014
• 单位华中科技大学