A QSAR study on inhibitory activities of 1-phenylbenzimidazoles against the platelet-derived growth factor receptor

作者：Zhong CL^*; He JT; Xue CY; Li YJ

来源：Bioorganic & Medicinal Chemistry, 2004, 12(15): 4009-4015.

DOI：10.1016/j.bmc.2004.06.002

• QSAR
• connectivity index
• the platelet-derived growth factor receptor

A quantitative structure-activity relationship (QSAR) study on inhibitory activities of 1-phenylbenzimidazoles against the platelet-derived growth factor receptor (PDGFR) was carried out in this work, and a QSAR model was developed. It gives an r(2) of 0.78 for the training set of 55 active compounds, and an r(2) of 0.75 for the test set of 24 active compounds. The new model was further applied to predict inhibitory activities of additional 44 inactive compounds, and very good agreement with experimental observations was obtained. The new model requires only variable connectivity indices and two position indices as input parameters, which is simple and easy to apply. The new model is useful for developing new anticancer drugs, which also demonstrates that the recently developed variable connectivity indices are very useful structural descriptors in the QSAR studies in the fields of pharmaceutics and biochemistry.

• 出版日期2004-8-1
• 单位北京化工大学