Association Between Interleukin-6 Gene-572G>C Polymorphism and Coronary Heart Disease

作者：Song, Chunli^*; Liu, Bin; Yang, Donghui; Diao, Hongying; Zhao, Liyan; Lu, Yang; Yu, Yunpeng; Guo, Ziyuan; Zhang, Jichang; Liu, Jiangen; Zhuo Zaho; Zhang, Xiaohao

来源：Cell Biochemistry and Biophysics, 2015, 71(1): 359-365.

DOI：10.1007/s12013-014-0206-z

• Interleukin 6
• Coronary heart disease
• Meta-analysis

The association of the Interleukin 6 (IL-6) -572G > C polymorphism and risk of coronary heart disease (CHD) have been implicated in a large number of investigations, but the results remain debatable. This meta-analysis was performed to provide more compelling evidence for the connection between the IL-6 -572G > C polymorphism and CHD risk. Studies eligible for this meta-analysis were identified through electronic search of PubMed, EMBASE, and CNKI. The fixed effects model was performed to summarize an odds ratio (OR) with 95 % confidence interval (CI). The meta-analysis of 3,985 patients and 7,153 controls from 17 studies showed that the CC genotype carriers had 0.84-fold lower risk of developing CHD when compared with the carriers with the GC+GG genotypes (ORCC vs. GC+GG = 0.84; 95 % CI = 0.75-0.95; P = 0.414; I (2) = 3.5 %). The decreased risk of CHD was also found in Asians (OR = 0.87; 95 % CI = 0.77-0.98; P = 0.227; I (2) = 22.7 %) and Caucasians (OR = 0.60; 95 % CI = 0.40-0.92; P = 0.958; I (2) = 0) under the same genetic comparison. The results of our meta-analysis revealed that the IL-6 -572G > C polymorphism may be linked with risk of CHD in a protective model.

• 出版日期2015-1
• 单位吉林大学