A prospective, randomized, triple-blind comparison of articaine and bupivacaine for maxillary infiltrations

作者：Vilchez Perez Miguel Angel; Sancho Puchades Manuel; Valmaseda Castellon Eduard; Paredes Garcia Jordi; Berini Aytes Leonardo; Gay Escoda Cosme^*

来源：Medicina Oral, Patologia Oral y Cirugia Bucal, 2012, 17(2): E325-E330.

DOI：10.4317/medoral.17476

• Articaine
• bupivacaine
• maxillary
• infiltrative anesthesia
• long-acting anesthetics

Objectives: To compare the clinical anesthetic efficacy of 0.5% bupivacaine and 4% articaine (both with 1:200.000 adrenaline) for anterior maxillary infiltration in healthy volunteers. %26lt;br%26gt;Material and methods: A triple-blind split-mouth randomized clinical trial was carried out in 20 volunteers. A supraperiosteal buccal injection of 0.9 ml of either solution at the apex of the lateral incisor was done in 2 appointments separated 2 weeks apart. The following outcome variables were measured: latency time, anesthetic efficacy (dental pulp, keratinized gingiva, alveolar mucosa and upper lip mucosa and tissue) and the duration of anesthetic effect. Hemodynamic parameters were monitored during the procedure. %26lt;br%26gt;Results: Latency time recorded was similar for both anesthetic solutions (p%26gt;0.05). No statistically significant differences were found in terms of anesthetic efficacy for dental pulp, keratinized gingiva or alveolar mucosa. Articaine had a significant higher proportion of successful anesthesia at 10 minutes after infiltration in lip mucosa and lip skin (p=0.039). The duration of anesthesia was 336 minutes for bupivacaine and 167 minutes for articaine. (p%26lt;0.001). No significant hemodynamic alterations were noted during the procedure. %26lt;br%26gt;Conclusions: Articaine and bupivacaine exhibited similar anesthetic efficacy for maxillary infiltrations. The duration of anesthesia was longer with the bupivacaine solution, but lip anesthesia was better with articaine.

• 出版日期2012-3