Diastereoselective formation of 2,3,4,5-tetrasubstituted tetrahydrofurans by a Lewis acid promoted addition of C3-substituted 1,3-bis(silyl)propenes to aldehydes

作者：Borg Tessie; Timmer Brian; Somfai Peter^*

来源：Tetrahedron Letters, 2013, 54(30): 3916-3918.

DOI：10.1016/j.tetlet.2013.05.016

• Tetrahydrofuran
• Allylsilanes
• Diastereoselectivity
• Lewis acid
• Aldehyde

A mild, efficient, Lewis acid promoted addition of C3-substituted 1,3-bis(silyl)propenes to aldehydes to provide the corresponding 2,3,4,5-tetrasubstituted tetrahydrofurans in excellent stereoselectivity is reported.

• 出版日期2013-7-24