Distribution of hepatitis C virus genotypes in an Argentine population

作者：Javier Chiesa Ignacio; Javier Serafino Juan; Gabriela Garcia Maria; Gabriel Nunez Guillermo; Silvia Perez Maria; Alberto Pirola Daniel

来源：Acta Bioquimica Clinica Latinoamericana, 2012, 46(4): 633-637.

• hepatitis C virus
• genotypes
• reverse hybridization

Six hepatitis C virus genotypes have been identified worldwide so far. These genotypes have been subclassified into different subtypes (a, b, c and others). It is known that the response to treatment is highly dependent on the genotype involved. The aim of this work was to assess the frequency of occurrence of the different HCV genotypes in the population of Argentina. To this end, 510 infected patients were subjected to HCV genotyping using the commercial kit Versant HCV genotype assay 2.0. Results indicated that the genotype 1 was the most frequent (67.6%), and that subtypes 1a and 1b showed a similar prevalence (33.3% and 34.5%, respectively). Genotypes 2 and 3 also displayed a similar frequency (14.5% and 14.5% respectively). This study provides an update regarding the frequency of all HCV genotypes circulating in Argentina. The results were obtained by the novel version of the genotyping kit, which enabled a correct subtyping of samples.

• 出版日期2012-12