Autophagy favors Brucella melitensis survival in infected macrophages

作者：Guo, Fei; Zhang, Hui; Chen, Chuangfu^*; Hu, Shengwei; Wang, Yuanzhi; Qiao, Jun; Ren, Yan; Zhang, Ke; Wang, Yong; Du, Guoqing

来源：Cellular and Molecular Biology Letters, 2012, 17(2): 249-257.

DOI：10.2478/s11658-012-0009-4

• Autophagy
• Brucella melitensis 16M
• LC3-II
• LC3-I
• Autophagosome
• Autophagy flux
• 3-Methyladenine
• Intracellular pathogens
• Murine macrophage RAW264.7
• Autophagic vesicle

This study investigated the role of autophagy in the survival of the invasive bacterium Brucella melitensis strain 16M in murine macrophages. Here, Brucella melitensis 16M was found to trigger autophagosome formation, enhance autophagy flux and increase the expression level of the autophagy marker protein LC3-II. When autophagy was pharmacologically inhibited by 3-methyladenine (3-MA), Brucella replication efficiency was significantly decreased (p < 0.05). These results suggest that autophagy favors Brucella melitensis 16M survival in murine macrophages.

• 出版日期2012-6
• 单位石河子大学