Alterations in extracellular tryptophan and dopamine concentrations in rat striatum following peripheral administration of D- and L-tryptophan: An in vivo microdialysis study

作者：Yoshihara Shunsuke; Otani Hayato; Tsunoda Makoto; Ishii Kana; Iizuka Hideaki; Ichiba Hideaki; Fukushima Takeshi^*

来源：Neuroscience Letters, 2012, 526(1): 74-78.

DOI：10.1016/j.neulet.2012.07.046

• Dopamine
• D-Tryptophan
• L-Tryptophan
• D-Amino acid oxidase
• Microdialysis
• Striatum
• 3-Methylpyrazole-5-carboxylic acid

Incorporation profiles of D-Trp and L-Trp into the striatum following intraperitoneal (i.p.) administration of D-Trp or L-Trp in male Sprague-Dawley rats (100 mg/kg) were investigated by using a brain microdialysis technique. Alterations in the extracellular dopamine (DA) concentration in the rat striatum were also examined. Incorporation profiles of D-Trp and L-Trp were almost identical; however, transient DA release was only observed 0-30 min following D-Trp administration. Pretreatment with 3-methylpyrazole-5-carboxylic acid, an inhibitor of D-amino acid oxidase (DAAO), significantly suppressed the DA release induced by D-Trp. These findings suggest that D-Trp-induced DA release may be mediated by certain D-Trp metabolites produced by DAAO.

• 出版日期2012-9-20