Amberlyst-15 mediated synthesis of 2-substituted 2,3-dihydroquinazolin-4(1H)-ones and their crystal structure analysis

作者：Murthy P Vns; Rambabu D; Krishna G Rama; Reddy C Malla; Prasad K R S; Rao M V Basaveswara; Pal Manojit^*

来源：Tetrahedron Letters, 2012, 53(7): 863-867.

DOI：10.1016/j.tetlet.2011.12.023

• 2,3-Dihydroquinazolin-4(1H)-ones, Aldehydes
• Amberlyst-15

An efficient and clean method has been developed for the synthesis of 2-substituted 2,3-dihydroquinazolin-4(1H)-ones using Amberlyst-15 as a recyclable catalyst. A variety of dihydroquinazolinones were prepared from 2-aminobenzamide and aldehydes under mild conditions in excellent yields. Further structure elaboration of one compound and the crystal structure analysis and hydrogen bonding patterns of the two compounds prepared by using this methodology is presented.

• 出版日期2012-2-15