A general route to unsubstituted N-aryl and heteroarylaminobenzenesulfonamides

作者：Lach Franck^*; Pasquet Marie Jeanne; Chabanne Mylene

来源：Tetrahedron Letters, 2011, 52(16): 1882-1887.

DOI：10.1016/j.tetlet.2011.02.034

• Buchwald-Hartwig coupling
• Sulfonamide
• Paramethoxybenzyl
• Protecting group

Starting from suitably protected 3- and 4-aminobenzenesulfonamides, a practical two-step strategy for the synthesis of unsubstituted N-aryl and heteroarylaminobenzenesulfonamides was devised. Strong bases are tolerated during the N-arylation step. Overall moderate to excellent yields are reported.

• 出版日期2011-4-20