Asc1, a WD-repeat protein, is required for hyphal development and virulence in Candida albicans

作者：Liu, Xiaoyan; Nie, Xinyi; Ding, Yufeng; Chen, Jiangye^*

来源：Acta Biochimica et Biophysica Sinica, 2010, 42(11): 793-800.

DOI：10.1093/abbs/gmq093

• Candida albicans
• Asc1
• hyphal development
• virulence

Candida albicans is a human pathogenic fungus which can undergo a morphological transition from yeast to hyphae in response to a variety of environmental stimuli. We analyzed a C. albicans Asc1 (Absence of growth Suppressor of Cyp1) protein which is entirely composed of seven repeats of the WD domain, and is conserved from fungi to metazoan. Deleting the ASC1 in C. albicans led to a profound defect in hyphal development under hypha-inducing conditions examined. Furthermore, deletion of the ASC1 attenuated virulence of C. albicans in a mouse model of systemic infection. These data strongly suggested that the conserved WD-repeat protein Asc1 is required for morphogenesis and pathogenesis of C. albicans.

• 出版日期2010-11
• 单位中国科学院; 中国科学院上海生命科学研究院; 分子生物学国家重点实验室