A novel surface modification on calcium polyphosphate scaffold for articular cartilage tissue engineering

作者：Lien Sio Mei; Liu Chun Kuo; Huang Ta Jen^*

来源：Materials Science and Engineering: C , 2007, 27(1): 127-134.

DOI：10.1016/j.msec.2006.04.004

• calcium phosphate
• cartilage
• degradation
• scaffolds
• surface modification

The surface of porous three-dimensional (3D) calcium polyphosphate (CPP) scaffold was modified by treatment of quenching-after-sintering in the fabrication process. Scanning electron microscopic examination and degradation tests confirmed a new type of surface modification. A rotary-shaking culture was compared to that of a stationary culture and the results showed that rotary shaking led to enhanced extracellular matrices (ECM) secretion of both proteoglycans and collagen. Rotary-shaking cultured results showed that the quenching-treated CPP scaffold produced a better cartilage tissue, with both proteoglycans and collagen secretions enhanced, than the air-cooled-after-sintering scaffolds. Moreover, beta-CPP scaffolds were better for the ECM secretion of both proteoglycans and collagen than the beta-CPP+gamma-CPP multiphase scaffold. However, the multiphase scaffold led to higher growth rate than that of beta-CPP scaffold; the quenching-after-sintering treatment reversed this. In addition, the ECM secretions of both proteoglycans and collagen in the quenching-treated beta-CPP scaffold were higher than those in the air-cooled one. Thus, the novel treatment of quenching-after-sintering has shown merits to the porous 3D CPP scaffolds for articular cartilage tissue engineering.

• 出版日期2007-1
• 单位清华大学