New insights into naevoid melanomas: a clinicopathological reassessment

作者：Cook Martin G^*; Massi Daniela; Blokx Willeke A M; Van den Oord Joost; Koljenovic Senada; De Giorgi Vincenzo; Kissin Eleanor; Grant Megan; Mandal Amit; Gremel Gabriela; Gaudy Caroline; Viros Amaya; Dhomen Nathalie; Khosrotehrani Kiarash; Marais Richard; Green Adele C; Mihm Martin C Jr

来源：Histopathology, 2017, 71(6): 943-950.

DOI：10.1111/his.13317

• immunohistochemistry
• maturing naevoid melanoma
• papillomatous naevoid melanoma
• paradoxical maturation
• small-cell melanoma

AimsBecause the term naevoid melanoma' has variable clinical and pathological interpretations, we aimed to clarify the features of melanomas referred to as naevoid.
Methods and resultsA review was undertaken of 102 melanomas diagnosed histopathologically as naevoid melanomas and ascertained by European Organization for Research and Treatment of Cancer Melanoma Group Subcommittee pathologists from their records. We found these could be classified morphologically into three groups. Thirteen melanomas were overlying genuine naevi and were therefore excluded. Of the 89 melanomas considered to be naevoid, 11 presented clinically as exophytic papillomatous nodules with little junctional component and composed of small atypical cells showing numerous mitoses and no change with depth; we termed these papillomatous naevoid' melanomas. The other 78 were flat or only slightly raised, and had a superficial spreading melanoma-like component with maturation to a small cell, but still an atypical, dermal component; we termed these maturing naevoid' melanomas. We showed that papillomatous and maturing naevoid melanomas also have differing immunochemical profiles. Preliminary clinical follow-up suggested different outcomes for these two naevoid melanoma types.
ConclusionsMelanomas that have been classified as naevoid melanomas comprise two types with distinct clinical, histopathological and immunohistochemical features that may also be prognostically significant.

• 出版日期2017-12
• 单位KU Leuven