Atrial remodeling in obstructive sleep apnea: Implications for atrial fibrillation

作者：Dimitri Hany; Ng Michelle; Brooks Anthony G; Kuklik Pawel; Stiles Martin K; Lau Dennis H; Antic Nicholas; Thornton Andrew; Saint David A; McEvoy Doug; Antic Ral; Kalman Jonathan M; Sanders Prashanthan^*

来源：Heart Rhythm, 2012, 9(3): 321-327.

DOI：10.1016/j.hrthm.2011.10.017

• Atrial fibrillation
• Arrhythmia
• Sleep apnea
• Hypoxia
• Remodeling

BACKGROUND There is a known association between obstructive sleep apnea (OSA) and atrial fibrillation (AF); however, how OSA affects the atrial myocardium is not well described. %26lt;br%26gt;OBJECTIVE To determine whether patients with OSA have an abnormal atrial substrate. %26lt;br%26gt;METHODS Forty patients undergoing ablation of paroxysmal AF and in sinus rhythm (20 with OSA [apnea-hypopnea index %26gt;= 15] and 20 reference patients with no OSA [apnea-hypopnea index %26lt; 15] by polysomnography) were studied. Multipolar catheters were positioned at the lateral right atrium (RA), coronary sinus, crista terminalis, and RA septum to determine the effective refractory period at 5 sites, conduction time along linear catheters at the RA and the coronary sinus, conduction at the crista terminalis, and sinus node corrected sinus node recovery time). Biatrial electroanatomic maps were created to determine the voltage, conduction, and distribution of complex electrograms (duration %26gt;= 50 ms). %26lt;br%26gt;RESULTS The groups had no differences in the prevalence of established risk factors for AF. Patients with OSA had the following compared with those without OSA: no difference in effective refractory period (P = .9), prolonged conduction times along the coronary sinus and RA (P = .02), greater number (P = .003) and duration (P = .03) of complex electrograms along the crista terminalis, longer P-wave duration (P = .01), longer corrected sinus node recovery time (P = .02), lower atrial voltage (RA, P %26lt; .001; left atrium, P %26lt; .001), slower atrial conduction velocity (RA, P = .001; left atrium, P = .02), and more widespread complex electrograms in both atria (RA, P = .02; left atrium, P = .01). %26lt;br%26gt;CONCLUSION OSA is associated with significant atrial remodeling characterized by atrial enlargement, reduction in voltage, sitespecific and widespread conduction abnormalities, and longer sinus node recovery. These features may in part explain the association between OSA and AF.

• 出版日期2012-3