Monitoring model drug microencapsulation in PLGA scaffolds using X-ray powder diffraction

作者：Aina Adeyinka^*; Gupta Manish; Boukari Yamina; Morris Andrew; Billa Nashiru; Doughty Stephen

来源：Saudi Pharmaceutical Journal, 2016, 24(2): 227-231.

DOI：10.1016/j.jsps.2015.03.015

• Encapsulation
• PLGA
• Model drugs
• XRPD

The microencapsulation of three model drugs; metronidazole, paracetamol and sulphapyridine into Poly (DL-Lactide-Co-Glycolide) (PLGA) scaffolds were probed using X-ray Powder Diffraction (XRPD). Changes in the diffraction patterns of the PLGA scaffolds after encapsulation was suggestive of a chemical interaction between the pure drugs and the scaffolds and not a physical intermixture.

• 出版日期2016-3