Postoperative early thromboembolism as a prognostic indicator in patients with curatively resected pancreatic cancer

作者：Hwang In Kyeom; Kang Bong Kyun; Lee Yoon Suk; Cho Jai Young; Yoon Yoo Seok; Hwang Jin Hyeok; Han Ho Seong; Kim Jaihwan^*

来源：American Journal of Surgery, 2015, 210(5): 871-877.

DOI：10.1016/j.amjsurg.2014.12.051

• Pancreatic neoplasms
• Surgery
• Thromboembolism
• Recurrence
• Prognosis

BACKGROUND: Information regarding postoperative thromboembolism in curatively resected pancreatic cancer is limited. This study aimed to assess the incidence and significance of postoperative thromboembolism.
METHODS: We retrospectively reviewed the medical records of 121 curatively resected pancreatic cancer patients. Early and late thromboembolisms were defined as events that occurred within 1 year and after 1 year, respectively.
RESULTS: Twenty-two patients (18%) experienced thromboembolism. Seven thromboembolic events occurred within 1 month (7, 6%), and the incidence rate decreased over time. Ten (63%) of the 16 patients with early thromboembolism experienced thromboembolism before or at the same time as recurrence; however, 5 (83%) of the 6 patients with late thromboembolism experienced recurrence before thromboembolism (P = .005). A significant difference in recurrence-free survival (P = .016) and borderline difference in overall survival (P = .050) were observed between patients with early thromboembolism and others.
CONCLUSIONS: Thromboembolic events after curative surgery are prevalent in pancreatic cancer, especially within 1 month. Thromboembolic events within 1 year of surgery should be cautiously monitored.

• 出版日期2015-11