Determination of Silodosin in Biological Samples Using UPLC-MS/MS Combined with Magnetic Carboxylated Multiwalled Carbon Nanotubes

作者：Yin, Q. H.; Zhu, Y. Q.; Yang, Y. L.^*

来源：Acta Chromatographica, 2018, 30(1): 47-53.

DOI：10.1556/1326.2016.00150

• Silodosin
• magnetic solid-phase extraction
• multiwalled carbon nanotubes
• biological samples
• UPLC-MS/MS

Novel magnetic solid-phase extraction using carboxylated multiwalled carbon nanotubes was proposed with ultra high-performance liquid chromatography-tandem mass spectrometry for the determination of silodosin in biological samples. The effects of various experimental parameters including adsorbent amount, pH, adsorption time, desorption conditions, and adsorbent reusability were systematically validated. Under the optimized conditions, the calibration curve was linear within the concentration range of 1.0-800 ng mL(-1) with the correlation coefficient of 0.9997 and the lower limit of detection was 0.3 ng mL(-1). The extraction recoveries were over 90.0% with relative standard deviation (RSD) of less than 5.0%. All these results suggested that magnetic extraction method can be used for enrichment and quantification of silodosin in biological samples.

• 出版日期2018-3
• 单位昆明理工大学