Hsa-miR-34b/c rs4938723 T>C, pri-miR-124-1 rs531564 C>G, pre-miR-125a rs12975333 G>T and hsa-miR-423 rs6505162 C>A polymorphisms and the risk of gastric cardia adenocarcinoma

作者：Singh, Dipak Kumar; Zhang, Wenbo; Xu, Ying; Yin, Jun; Gu, Haiyong^*; Jiang, Pengcheng^*

来源：International Journal of Clinical and Experimental Medicine, 2017, 10(10): 14919-14926.

• Gastric cardia adenocarcinoma
• single nucleotide polymorphism
• microRNA
• miR-423
• rs6505162
• risk of cancer

Gastric cardia adenocarcinoma (GCA) is among the leading causes of cancer related deaths and its incidence is increasing recently. Along with environmental factors, genetic factors might also play an important role in the carcinogenesis of GCA. We conducted a hospital based case-control study to evaluate the effect of single nucleotide polymorphisms (SNPs) in Hsa-miR-34b/c rs4938723 T>C, pri-miR-124-1 rs531564 C>G, pre-miR-125a rs12975333 G>T and hsa-miR-423 rs6505162 C>A on the risk of GCA. A total of 330 cases and 608 controls were recruited for the study. Ligation detection reaction (LDR) method was used to determine individual genotypes. No significant association was observed between these SNPs and overall GCA risk in all genetic comparison models, respectively. However, in stratification analysis, SNP in hsa-miR-423 rs6505162 C>A was associated with increased risk of GCA in female patients, whereas decreased risk of GCA in male patients. Further large scale studies in different ethnic groups are warranted to validate these findings.

• 出版日期2017
• 单位江苏大学; 上海交通大学