科研之友
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摘要
Epilepsy is an abnormality of nervous system showing seizures. Despite, the known antiepileptic activity of plants possessing anti-oxidant properties, Silybum marianum has not been studied yet. Therefore, present experiment was planned to evaluate antiepileptic potential of S. marianum (100, 200 and 300 mg/kg) seeds ethanol extract in pentylenetetrazol-induced kindled mice (n = 30). S. marianum seed extract (300 mg/kg) provided significant protection against pentylenetetrazol-induced convulsions (seizure intensity, latency and lethality) comparable with reference drug (valproic acid). Furthermore, 300 mg/kg/day dose was effective to prevent oxidative stress causing significant decrease in the lipid peroxidation (1.4 +/- 0.4 nmol/mg protein) and increased superoxide dismutase (0.4 +/- 0.1 mu mol/mg protein) and catalase activity (4.7 +/- 0.8 U/mL) of mice brain as compared to induced untreated group (p<0.05). It was concluded that antiepileptic activity of S. marianum seeds was due to its anti-oxidant property.
- 出版日期2016
