A series of critically challenging case scenarios in moderate to severe psoriasis: A Delphi consensus approach

作者：Strober Bruce^*; Berger Emily; Cather Jennifer; Cohen David; Crowley Jeffrey J; Gordon Kenneth B; Gottlieb Alice; Horn Elizabeth J; Kavanaugh Arthur E; Korman Neal J; Krueger Gerald G; Leonardi Craig L; Menter Alan; Schwartzman Sergio; Sobell Jeffrey M; Young Melodie

来源：Journal of the American Academy of Dermatology, 2009, 61(1): S1-S46.

DOI：10.1016/j.jaad.2009.03.017

Clinical trials for systemic psoriasis therapy typically enroll healthy patients exclude patients with cardiovascular disease, latent tuberculosis, liver disease, histories of malignancies, viral infections, children, and pregnant or breast-feeding women. Physicians often require guidance for optimum management of severe psoriasis in patients that have a combination of underlying disease states. To provide treatment recommendations for complex psoriasis scenarios, a consensus panel comprising 15 experts in psoriatic disease convened to review and discuss available evidence-based data and to arrive at a consensus for treatment options of difficult cases. An application of the Delphi Method was used to select case scenarios. provide medical treatment options, present the case study with existing medical evidence, and anonymously vote on treatment options. The top 10 treatment options were ranked and statistically analyzed to compare the differences between treatments. The final rankings and analysis provide guidance for practical, safe, and efficacious treatment options in a number)er of complex psoriasis scenarios. (J Am Acad Dermatol 2008;61:S1-46.)

• 出版日期2009-7