Adenosine: An endogenous mediator in the pathogenesis of gynecological cancer

作者：Bahreyni Amirhossein; Samani Seyed S; Ghorbani Elnaz; Rahmani Farzad; Khayami Reza; Toroghian Younes; Behnam Rassouli Reihane; Khazaei Majid; Ryzhikov Mikhail; Parizadeh Mohammad R; Hasanzadeh Malihe; Avan Amir^*; Hassanian Seyed M^*

来源：Journal of Cellular Physiology, 2018, 233(4): 2715-2722.

DOI：10.1002/jcp.26056

• adenosine
• adenosine signaling
• gynecological cancer

Extracellular concentration of adenosine increases in the hypoxic tumor microenvironment. Adenosine signaling regulates apoptosis, angiogenesis, metastasis, and immune suppression in cancer cells. Adenosine-induced cell responses depend upon different subtypes of adenosine receptors activation and type of cancer. Suppression of adenosine signaling via inhibition of adenosine receptors or adenosine generating enzymes including CD39 and CD73 on ovarian or cervical cancer cells is a potentially novel therapeutic approach for gynecological cancer patients. This review summarizes the role of adenosine in the pathogenesis of gynecological cancer for a better understanding and hence a better management of this disease.

• 出版日期2018-4