ALVEOLAR RHABDOMYOSARCOMA - PRIMARY AND RECURRENT METASTATIC TUMOR HAS CHROMOSOMAL TRANSLOCATION T(2-13)(Q37-Q14), AMPLIFIED N-MYC AND IS TUMORIGENIC IN NUDE-MICE

作者：DIAS P^*; KUMAR P; MARSDEN HB; GATTAMANENI HR; HEIGHWAY J; KUMAR S

来源：International Journal of Oncology, 1992, 1(1): 47-51.

• RHABDOMYOSARCOMA
• CHROMOSOMAL TRANSLOCATION
• N-MYC

Tissue specimens of primary and recurrent metastatic alveolar rhabdomyosarcoma (A-RMS) from a 12 year old child were cultured and shown to contain A-RMS specific t(2;13) (q37;q14) chromosomal translocation and to be tumourigenic in nude mice. Whereas c-myc protooncogene was neither amplified nor grossly rearranged, both biopsy samples were demonstrated to have 5-fold amplification of N-myc gene sequence. N-myc gene was also amplified in cell cultures produced by primary and metastatic tumour biopsies. Such a model for A-RMS has not been previously available.

• 出版日期1992-6