Acoschimperoside P, 2 '-acetate: a Hedgehog signaling inhibitory constituent from Vallaris glabra

作者：Rifai Yusnita; Arai Midori A; Koyano Takashi; Kowithayakorn Thaworn; Ishibashi Masami^*

来源：Journal of Natural Medicines, 2011, 65(3-4): 629-632.

DOI：10.1007/s11418-011-0530-1

• Acoschimperoside P, 2 '-acetate
• Vallaris glabra
• Hedgehog/GLI signaling inhibitors

Complete (1)H and (13)C NMR assignments of acoschimperoside P, 2'-acetate (1) and a new cardiac glycoside (2), isolated from the leaves of Vallaris glabra, are described. Compound 1 was active in the assay for Hedgehog signaling inhibition. In further experiments, this compound showed a strong cytotoxicity against human pancreatic (PANC1) and human prostate (DU145) cancer cells. The expression of GLI-related proteins (PTCH and BCL-2) in a dose-dependent manner was also inhibited by 1.

• 出版日期2011-7