Association of tryptophan hydroxylase-2 polymorphisms with oppositional defiant disorder in a Chinese Han population

作者：Wang, Chang-Hong; Liu, Cong; Cong, En-Zhao; Xu, Gai-Ling; Lv, Ting-Ting; Zhang, Ying-Li; Ning, Qiu-Fen; Wang, Ji-Kang; Nie, Hui-Yao^*; Li, Yan^*

来源：Behavioral and Brain Functions, 2016, 12(1): 30.

DOI：10.1186/s12993-016-0113-0

• Oppositional defiant disorder
• Tryptophan hydroxylase-2 gene
• Single nucleotide polymorphisms

Background: Oppositional defiant disorder (ODD) is a behavioral disorder of school-age population. It is well known that 5-HT dysfunction is correlated with impulsivity, which is one of the common characteristics of ODD. The enzyme tryptophan hydroxylase-2 (TPH-2) synthesizes 5-HT in serotonergic neurons of the midbrain raphe. The purposes of this study were to investigate the potential association of TPH-2 polymorphisms with susceptibility to ODD in a Han Chinese school population. Methods: Four polymorphisms (rs4570625, rs11178997, rs1386494 and rs7305115) of the TPH-2 gene were analyzed by using polymerase chain reaction and DNA microarray hybridization in a case-control study of 276 Han Chinese individuals (124 ODD and 152 controls). Results: In single marker analyses, there was a significant difference in the genotype (x(2) = 4.163, P = 0.041) and allele frequency (x(2) = 3.930, P = 0.047) of rs1386494 between ODD and control groups. Haplotype analyses revealed higher frequencies of haplotypes TA (rs4570625-rs11178997), TAG (rs4570625-rs11178997-rs1386494), TAA (rs4570625-rs11178997-rs7305115) and TAGA (rs4570625-rs11178997-rs1386494-rs7305115), but lower frequencies of haplotypes GA (rs4570625-rs11178997) and GAG (rs4570625-rs11178997-rs1386494) in ODD compared to control groups. Conclusions: These findings suggest the role of these TPH-2 gene variants in susceptibility to ODD. Some haplotypes might be the risk factors for Chinese Han children with ODD, while others might be preventable factors.

• 出版日期2016-11-21
• 单位新乡医学院; 郑州大学