Analysis of the transforming growth factor beta 1 gene-509 C/T polymorphism in patients with advanced-stage endometriosis

作者：Kim Jin Ju; Choi Young Min^*; Choung Seon Ha; Yoon Sang Ho; Lee Kyu Sup; Ku Seung Yup; Kim Jung Gu; Moon Shin Yong

来源：Fertility and Sterility, 2010, 93(7): 2121-2124.

DOI：10.1016/j.fertnstert.2009.01.082

• Endometriosis
• transforming growth factor beta 1
• polymorphism

Objective: To investigate whether the transforming growth factor beta (TGF-beta) gene -509 C/T polymorphism is associated with susceptibility to advanced-stage endometriosis.
Design: Case-control study.
Setting: University department of obstetrics and gynecology.
Patient(s): Women with advanced-stage endometriosis (n = 485) and without endometriosis (n 352).
Intervention(s): Genotyping by real-time polymerase chain reaction using a Taqman assay.
Main Outcome Measure(s): Genotype distribution and allele frequency of the -509 C/T polymorphism in the TGF-beta 1 gene.
Result(s): The genotype distribution of the TGF-beta 1 gene -509 C/T polymorphism in the endometriosis group was not different from that of the control group (CC/CT/TT rates were 29.3%/48.2%/22.5% and 27.3%/50.3%/22.4% for the endometriosis and control groups, respectively). Further subgroup analyses according to the stage of endometriosis or bilaterality of ovarian endometrioma also revealed no significant differences in the genotype distribution between each of the subgroups and the control group.
Conclusion(s): These results suggest that the TGF-beta 1 -509 C/T polymorphism may not be associated with an increased risk for advanced-stage endometriosis. (Fertil Steril (R) 2010;93:2121-4.

• 出版日期2010-5-1