Accuracy of low-dose rubidium-82 myocardial perfusion imaging for detection of coronary artery disease using 3D PET and normal database interpretation

作者：Kaster Tyler; Mylonas Ilias; Renaud Jennifer M; Wells George A; Beanlands Rob S B; deKemp Robert A^*

来源：Journal of Nuclear Cardiology, 2012, 19(6): 1135-1145.

DOI：10.1007/s12350-012-9621-y

• PET-CT
• myocardial perfusion imaging
• normal relative perfusion
• coronary artery disease
• quantification

Background. Our aim was to develop a normal database to be used for quantification of myocardial perfusion and diagnosis of %26quot;obstructive coronary artery disease%26quot; (CAD) using low-dose rubidium-82 three-dimensional (3D) positron emission tomography (PET)-CT. %26lt;br%26gt;Methods. From a record of 1,501 patients, 77 were identified as having low-likelihood (LLK) of CAD. Forty LLK patients were used to construct a normal database using 4DM-PET, the remainder used for validation of normalcy. A group of 70 patients with CAD who had invasive coronary angiography and PET-CT were used to evaluate the accuracy of the database for detecting CAD using the sum-stress-score. The effect of clinical exclusion criteria and the inclusion of LLK patients were evaluated. %26lt;br%26gt;Results. The normal database for CAD detection had a normalcy rate of 95%. Sensitivity was 100% for detecting patients with either 50% or 70% stenosis. Optimal specificity was 87% for either 50% or 70% stenosis. For localizing disease at 50% stenosis in the left anterior descending, left circumflex, and right coronary artery, sensitivity ranged from 59% to 68%, while specificity was maintained at 87-89%. Similarly, at 70% stenosis, sensitivity ranged from 64% to 79%, and specificity from 87% to 91%. %26lt;br%26gt;Conclusions. A normal database containing the relative perfusion scores of patients with LLK of CAD can be used to accurately diagnose obstructive coronary disease using low-dose Rb-82 with 3D PET-CT imaging. (J Nucl Cardiol 2012;19:1135-45.)

• 出版日期2012-12